An extended stay in a remote Antarctic research station is the closest thing to a long space journey that humans can experience without leaving Earth. But scientists have discovered that the isolation and unchanging views have an impact on the human brain and cognitive abilities. The study was small, so more research needs to be done. However, the finding could be important for Earth-bound researchers, as well as for future inter-planetary travellers.
The Live Science website has the story: https://www.livescience.com/antarctic-expedition-changes-the-brain.html